• Adiponectin prevents orthodontic tooth movement in rats 

      Haugen, Sigrid; Aasarød, Kristin Matre; Stunes, Astrid Kamilla; Mosti, Mats Peder; Franzen, Tanya Jeanette; Vandevska-Radunovic, Vaska; Syversen, Unni; Reseland, Janne Elin (Journal article; Peer reviewed, 2017)
      Objective The objective was to examine the effects of repetitive local administration of adiponectin on experimental tooth movement in rats. Materials and methods The maxillary right first molar of male Wistar rats ...
    • Adiponectin reduces bone stiffness; verified in a 3D artificial human bone model in vitro 

      Haugen, Sigrid; He, Jianying; Sundaresan, Alamelu; Stunes, Astrid Kamilla; Aasarød, Kristin Matre; Tiainen, Hanna; Syversen, Unni; Skallerud, Bjørn Helge; Reseland, Janne Elin (Journal article; Peer reviewed, 2018)
      Primary human osteoblasts and osteoclasts incubated in a rotating coculture system without any scaffolding material, form bone-like tissue that may be used to evaluate effects of various compounds on mechanical strength. ...
    • Alendronate and omeprazole in combination reduce angiogenic and growth signals from osteoblasts 

      Kruger, Tormod Bjartveit; Herlofson, Bente Brokstad; Lian, Aina-Mari; Syversen, Unni; Reseland, Janne Elin (Peer reviewed; Journal article, 2021)
      Objective: Due to gastrointestinal side effects of oral bisphosphonates (BPs), proton pump inhibitors (PPIs) are often prescribed. PPIs may enhance the risk of osteonecrosis of the jaw, a rare side effect of BPs. Therefore, ...
    • The dose-dependent impact of γ-radiation reinforced with backscatter from titanium on primary human osteoblasts 

      Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike Jeppesen; Tiainen, Hanna; Ellingsen, Jan Eirik (Peer reviewed; Journal article, 2023)
      In head and neck cancer patients receiving dental implants prior to radiotherapy, backscatter from titanium increases the radiation dose close to the surface, and may affect the osseointegration. The dose-dependent effects ...
    • Early evolution of enamel matrix proteins is reflected by pleiotropy of physiological functions 

      Spoutil, Frantisek; Aranaz-Novaliches, Goretti; Prochazkova, Michaela; Wald, Tomas; Novosadova, Vendula; Kasparek, Petr; Osicka, Radim; Reseland, Janne Elin; Lyngstadaas, Ståle Petter; Tiainen, Hanna; Bousova, Kristyna; Vondrasek, Jiri; Sedlacek, Radislav; Prochazka, Jan (Peer reviewed; Journal article, 2023)
      Highly specialized enamel matrix proteins (EMPs) are predominantly expressed in odontogenic tissues and diverged from common ancestral gene. They are crucial for the maturation of enamel and its extreme complexity in ...
    • Irisin reduces orthodontic tooth movement in rats by promoting the osteogenic potential in the periodontal ligament 

      Yang, Yang; Pullisaar, Helen; Stunes, Astrid Kamilla; Parreiras Nogueira, Liebert; Syversen, Unni; Reseland, Janne Elin (Peer reviewed; Journal article, 2023)
      Objectives Positive effects of irisin on osteogenic differentiation of periodontal ligament (PDL) cells have been identified previously, this study aims to examine its effect on orthodontic tooth movement (OTM) in ...
    • Osteocyte-Like Cells Differentiated From Primary Osteoblasts in an Artificial Human Bone Tissue Model 

      Munir, Arooj; Reseland, Janne Elin; Tiainen, Hanna; Haugen, Håvard Jostein; Sikorski, Pawel; Christiansen, Emil; Reinholt, Finn P.; Syversen, Unni; Solberg, Lene Bergendal (Peer reviewed; Journal article, 2023)
      In vitro models of primary human osteocytes embedded in natural mineralized matrix without artificial scaffolds are lacking. We have established cell culture conditions that favored the natural 3D orientation of the bone ...
    • Skeletal effects of the saturated 3-thia fatty acid tetradecylthioacetic acid in rats 

      Stunes, Astrid Kamilla; Westbroek, Irene; Fossmark, Reidar; Berge, Rolf Kristian; Reseland, Janne Elin; Syversen, Unni (Journal article; Peer reviewed, 2011)
      This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), ...
    • Targeting a therapeutically relevant concentration of alendronate for in vitro studies on osteoblasts 

      Krüger, Tormod Bjartveit; Syversen, Unni; Herlofson, Bente Brokstad; Lian, Aina-Mari; Reseland, Janne Elin (Peer reviewed; Journal article, 2022)
      Objective Bisphosphonates like alendronate mainly exert their effects on osteoclasts. However, osteoblasts are also affected, but exposed to a much lower concentration in vivo than the osteoclasts. Given that the effects ...
    • The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats 

      Stunes, Astrid Kamilla; Westbroek, Irene; Gustafsson, Björn; Fossmark, Reidar; Waarsing, Jan H; Eriksen, Erik Fink; Petzold, Christiane; Reseland, Janne Elin; Syversen, Unni (Journal article; Peer reviewed, 2011)
      Background Activation of peroxisome proliferator-activated receptor (PPAR)gamma is associated with bone loss and increased fracture risk, while PPARalpha activation seems to have positive skeletal effects. To further ...
    • Vitamin K2 modulates vitamin D induced mechanical properties of human 3D bone spheroids in vitro 

      Schröder, Maria; Riksen, Elisabeth Aurstad; He, Jianying; Skallerud, Bjørn Helge; Møller, Mona Elisabeth; Lian, Aina-Mari; Syversen, Unni; Reseland, Janne Elin (Peer reviewed; Journal article, 2020)
      Rotational culture promotes primary human osteoblasts (hOBs) to form three-dimensional (3D) multicellular spheroids with bone tissue-like structure without any scaffolding material. Cell-based bone models enable us to ...